经过一番艰难的考验，吊儿郎当的人类青年乔纳森（安迪·萨姆伯格 Andy Samberg 配音）终于和吸血鬼女郎梅菲丝（赛琳娜·戈麦斯 Selena Gomez 配音）携手走入婚姻的殿堂，而以梅菲丝的父亲德古拉（亚当·桑德勒 Adam Sandler 配音）为代表的怪物们，和人类的关系前所未有地密切起来。婚后不久，梅菲丝生下了可爱的儿子丹尼斯。小家伙一天天长大，外公德古拉对他疼爱有加，他热切期望丹尼斯能够成长为出色的吸血鬼。与之相对，梅菲丝认定儿子是一个普通的人类小孩，她希望能带丹尼斯走进文明社会，远离暴力血腥的怪物世界。为了阻止女儿一家的离开，德古拉想办法支走梅菲丝，同时叫上科学怪人、狼人、透明人、木乃伊等一帮死党，要在有限的时间里对丹尼斯展开一场吸血鬼养成教育集训。 　　两代人的观念分歧，在怪物的世界中也不例外……The Drac pack is back for an all-new monster comedy adventure in Sony Pictures Animation's Hotel Transylvania 2! Everything seems to be changing for the better at Hotel Transylvania... Dracula's rigid monster-only hotel policy has finally relaxed, opening up its doors to human guests. But behind closed coffins, Drac is worried that his adorable half-human, half-vampire grandson, Dennis, isn't showing signs of being a vampire. So while Mavis is busy visiting her human in-laws with Johnny - and in for a major cultural shock of her own - "Vampa" Drac enlists his friends Frank, Murray, Wayne and Griffin to put Dennis through a "monster-in-training" boot camp. But little do they know that Drac's grumpy and very old, old, old school dad Vlad is about to pay a family visit to the hotel. And when Vlad finds out that his great-grandson is not a pure blood - and humans are now welcome at Hotel Transylvania - things are going to get batty!