纽约曼哈顿区的娜奥米和伊莱做了一辈子的邻居＋闺/gay密，虽然两家的上一代纠缠不清，但这对无坚不摧的死党相信没有任何男人可以插足他们，为此他们发明了“不接吻名单”，只要上了名单的人大家都不去触碰。只是计划始终没有变化快，伊莱意外对娜奥米的男友产生了好感，而娜奥米原来一直偷偷喜欢着伊莱！这是一个“腐女爱着基友，腐女把男友输给了基友”的故事，讲述轻松流畅不闹心的纽约爱情和友情。电影阵容包括众多青少年鲜肉，剧本出自“舞出我人生3”的Amy Andelson。Naomi and Ely have loved each other their whole lives, even though Ely isn't exactly into girls. The institution of a "No Kiss List" has prevented the two from rifts in the past, but bonds are tested when they both fall for the same guy.