霍金（埃迪·雷德梅恩 Eddie Redmayne 饰）和简（菲丽希缇·琼斯 Felicity Jones 饰）相识于一场舞会上，两人初次见面交谈甚欢，颇有一番相见恨晚的意味。之后，霍金大胆的邀请简参加舞会，二人以此为契机，陷入了热恋之中。 　　不幸的是，一次昏迷令霍金被确诊患上了罕见的肌萎缩性侧索硬化症（ALS），医生坦言他只剩两年的生命，被病魔折磨的霍金陷入了抑郁之中，然而简并没有因此而抛弃他，恰恰相反，几经波折之后，两人踏入了婚姻的殿堂，简还为霍金生下了一个活泼可爱的孩子。霍金的身体迅速的虚弱下来，与此同时，他在学术研究上却取得了一个又一个成就。为了照顾霍金，简心甘情愿成为了他“背后的女人”，但是，这也恰恰成为了两人幸福婚姻里的第一道裂缝。The Theory of Everything is the story of the most brilliant and celebrated physicist of our time, Stephen Hawking, and Jane Wilde the arts student he fell in love with whilst studying at Cambridge in the 1960s. Little was expected from Stephen Hawking, a bright but shiftless student of cosmology, given just two years to live following the diagnosis of a fatal illness at 21 years of age. He became galvanized, however, by the love of fellow Cambridge student, Jane Wilde, and he went on to be called the successor to Einstein, as well as a husband and father to their three children. Over the course of their marriage as Stephen's body collapsed and his academic renown soared, fault lines were exposed that tested the lineaments of their relationship and dramatically altered the course of both of their lives.