19世纪80年代，美国帝国主义四出扩张，对殖民地进行疯狂的洗掠。一时间，殖民地人民纷纷建立起了反抗军，对抗美帝国主义。墨西哥当时也是美帝的殖民地，萨拉（萨尔玛•海耶克 Salma Hayek 饰）是当地一位银行家的女儿，虽然自小就被精心培养成标准的“欧洲淑女”。但萨拉却是一身豪气侠胆，被美帝夺取了家里的财产后，萨拉开始了武装抢劫美帝的银行之旅。 　　玛丽亚（佩内洛普•克鲁兹 Penélope Cruz 饰）是当地一户农户的女儿，因父亲被美兵殴打伤重，点燃了她对美帝的仇恨之火，玛丽亚也开始抢劫美帝的银行。 　　两个女孩在一次抢劫银行时偶遇了，从此她们结束了单打独斗，联合起来共同对付美帝。In 1848, a New York bank wants to put a railroad across Mexico, so it buys up small banks around Santa Rita, Durango, and evicts farmers on the proposed rail line who owe money. The bank's henchman is the murderous Jackson. He runs afoul of two women, María, the tough but uneducated daughter of a farmer, and Sara, the European-educated daughter of the owner of one of these banks. To feed the now landless people and to seek revenge, María and Sara become bank robbers, veritable Robin Hoods. But Jackson and his hired guns are after them. What are the women's options?