罗拉•克劳福特（安吉丽娜•朱莉 饰）这名勇于挑战的探险家继续她的探索之路。这次是寻找早已沉入大海的月神庙。根据资料显示，月神庙内埋藏了传说中的“潘朵拉魔盒”。而一股巨大的能量正存在与这个魔盒当中，同时间邪恶的势力也对这个股力量虎视眈眈。因为这股力量的巨大能足以摧毁整个人类世界，邪恶的势力企图利用的话后果不堪设想。 　　罗拉一边寻找这股传说中的神奇力量，一边与香港黑帮的头目斗智斗勇。到底罗拉能不能顺利获得这股力量，保卫整个人类世界的安全呢？Intrepid British archaeologist Lara Croft has made perhaps the most important archaeological discovery in history: an orb that leads to the mythical Pandora's Box. Unfortunately, the orb falls into the hands of Jonathan Reiss, an evil scientist who deals in killer viruses and hopes to sell the secrets of the box as the ultimate weapon. Recruited by British Intelligence to get the orb back from Reiss, Lara recruits Terry Sheridan, a British marine turned mercenary (and her former love interest) to help. The two embark on an adventure that spans continents in an attempt to regain the orb...