奥黛丽（米拉·库妮丝 饰）和摩根（凯特·迈克金农 饰）两位好闺蜜，因奥黛丽前男友的间谍身份，意外被卷入一场国际阴谋，她们开始与各位杀手斗智斗勇，在一名可疑但有魅力的英国特工带领下，实施拯救世界的计划，在欧洲大陆上演惊心动魄又啼笑皆非的国际逃亡之旅。Audrey (Mila Kunis) and Morgan (Kate McKinnon), two thirty-year-old best friends in Los Angeles, are thrust unexpectedly into an international conspiracy when Audrey's ex-boyfriend shows up at their apartment with a team of deadly assassins on his trail. Surprising even themselves, the duo jump into action, on the run throughout Europe from assassins and a suspicious-but-charming British agent, as they hatch a plan to save the world.