布特（古斯塔夫·冯·沃根海姆 Gustav von Wangenheim 饰）是一家不来梅地产公司的职员，受公司委派去一座古堡与诺斯费拉图伯爵（马科斯·夏瑞克 Max Schreck 饰）做房屋买卖交易，但是在古堡附近的旅店投宿时，人们得知他目的地的反应都很奇怪。到了古堡，见到面目枯槁、行为古怪的诺斯费拉图伯爵，也得知他昼伏夜出的生活习惯，布特对他的身份心生窦疑，终于探知他就是传说中的吸血鬼。布特逃出古堡，伯爵也一路奔向他买好的、位于不来梅的房子。布特回家后，得知吸血鬼伯爵已经到来，而且正是他令小城瘟疫肆虐，他和妻子艾伦（Greta Schröder 饰）一起，开始设法消灭吸血鬼伯爵……Wisbourg, Germany based estate agent Knock dispatches his associate, Hutter, to Count Orlok's castle in Transylvania as the Count wants to purchase an isolated house in Wisbourg. They plan on selling him the one across the way from Hutter's own home. Hutter leaves his innocent wife, Ellen, with some friends while he is away. Hutter's trek is an unusual one, with many locals not wanting to take him near the castle where strange events have been occurring. Once at the castle, Hutter does manage to sell the Count the house, but he also notices and feels unusual occurrences, primarily feeling like there is a dark shadow hanging over him, even in the daytime when the Count is unusually asleep. Hutter eventually sees the Count's sleeping chamber in a crypt, and based on a book he has recently read, believes the Count is really a vampire or Nosferatu. While Hutter is trapped in the castle, the Count, hiding in a shipment of coffins, makes his way to Wisbourg, causing death along his way, which most attribute to the plague. Hutter himself tries to rush home to save his town and most importantly save Ellen from Nosferatu's imminent arrival. In Wisbourg, Ellen can feel the impending darkness as Nosferatu gets closer. But she learns that a sinless woman can sacrifice herself to kill the vampire. Will Hutter be able to save Ellen either from Nosferatu and/or her self-sacrifice?